Living well with diabetes involves a significant number decisions, from day-to-day management of the disease, to choices that are influenced by events outside of our immediate control. Through Audience Perspectives, we visit the true meaning of the word difficult, successes and challenges in diabetes education, and an overview of how the Affordable Care Act is working for people with diabetes. Research and review articles highlight the daily physiological and psychological challenges faced by people living with diabetes and include recommendations for improving patient outcomes. Articles in Moving Forward conclude the issue with a discussion about the importance of understanding the illness experiences of patients living with diabetes and other chronic conditions. Engaged and empowered patients, e-patients, have the opportunity to be partners in their care, working with providers and researchers to find better solutions to complex health problems.